'Funny' current: if heart rate slowing is not the best answer, what might be?
نویسنده
چکیده
منابع مشابه
Intracardiac Origin of Heart Rate Variability, Pacemaker Funny Current and their Possible Association with Critical Illness
Heart rate variability (HRV) is an indirect estimator of autonomic modulation of heart rate and is considered a risk marker in critical illness, particularly in heart failure and severe sepsis. A reduced HRV has been found in critically ill patients and has been associated with neuro-autonomic uncoupling or decreased baroreflex sensitivity. However, results from human and animal experimental st...
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It should not be ignored that our interpreting the HF power in the heart frequency spectrum as indicating an increase in cardiac parasympathetic activity was only one part of our argument. There are three points we now wish to further emphasise. One is that blocking the If pacemaker current and slowing heart rate does not change the power of the HF component in humans as we previously cited and...
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The Rockefeller University Press $30.00 J. Gen. Physiol. 2017 Vol. 149 No. 2 177–179 https://doi.org/10.1085/jgp.201611746 177 Although many of us optimistically try to be “younger next year” (Crowley and Lodge, 2004), there is one inescapable fact: maximum heart rate declines over the decades regardless of fitness level. A parallel decrease in our so-called intrinsic heart rate, measured in th...
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"Funny" (f) channels underlie the cardiac "pacemaker"I(f) current, originally described as an inward current activated on hyperpolarization to the diastolic range of voltages in sino-atrial node myocytes [Brown, HF, DiFrancesco, D, Noble, SJ. How does adrenaline accelerate the heart? Nature 1979;280:235-236]. The involvement of funny channels in the generation and modulation of cardiac pacemake...
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عنوان ژورنال:
- Cardiovascular research
دوره 84 1 شماره
صفحات -
تاریخ انتشار 2009